7-(Azidomethyl)quinoline → Quinolin-7-ylmethanamine
반응식
[N:1]([CH2:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][CH:11]=[N:12]2)=[CH:7][CH:6]=1)=[N+]=[N-]>[Ni].CO>[N:12]1[C:13]2[C:8](=[CH:7][CH:6]=[C:5]([CH2:4][NH2:1])[CH:14]=2)[CH:9]=[CH:10][CH:11]=1참가 물질
4
실험 절차
7-(Azidomethyl)quinoline (1.1 g, 5.7 mmol) was hydrogenated (1 atm) in the presence of Raney nickel (1.5 g, 26 mmol) in methanol (30 mL) until completion of the reaction. Catalyst was filtered off and the filtrate was concentrated under reduced pressure to a yellow oil which was dissolved in EtOAc (32 mL) and extracted with 1N hydrochloric acid (3×32 mL). The combined acidic aqueous phases were adjust to pH˜10 with 1N sodium hydroxide solution, and extracted with EtOAc (3×35 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated under reduced pressure to afford a white solid (0.89 g, 94%).
후처리
- customuntil completion of the reaction
- filtrationCatalyst was filtered off
- concentrationthe filtrate was concentrated under reduced pressure to a yellow oil which
- dissolutionwas dissolved in EtOAc (32 mL)
- extractionextracted with 1N hydrochloric acid (3×32 mL)
- extractionextracted with EtOAc (3×35 mL)
- dry with materialThe combined organic layers were dried over MgSO4
- filtrationfiltered
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-12c48e6fd3ec4232afc27eb37e2f6f68
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076345B2
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