2,2,2-Trifluoroethanol → 6-(2,2,2-Trifluoroethoxy)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

HRID 657852노트

반응식

HRID 657852 반응식
[F:1][C:2]([F:6])([F:5])[CH2:3][OH:4].[H-].[Na+].Br.Cl[C:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:17]([NH2:20])=[N:18][N:19]=2)[N:16]=1>>[F:1][C:2]([F:6])([F:5])[CH2:3][O:4][C:11]1[CH:12]=[CH:13][C:14]2[N:15]([C:17]([NH2:20])=[N:18][N:19]=2)[N:16]=1

참가 물질

4

반응물 3

HCID 64092,2,2-TrifluoroethanolHCID 24758Sodium hydrideHCID 866507946-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide

생성물 1

HCID 581368996-(2,2,2-Trifluoroethoxy)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine

실험 절차

2,2,2-Trifluoroethanol (1 ml), sodium hydride (86 mg) and 6-chloro-[1,2,4]triazolo[4,3-b]pyridazin-3-ylamine hydrobromide (W2.001, 100 mg) were reacted according to W1.004. 87 mg of the title compound were obtained in solid form.

출처 및 근거

ORD 기록
ord-2fa4303b95284093a54447c62bcb67dd
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076336B2

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