Isopropanol → 2-Cyclohexen-1-one, 2,5,6-trimethyl-

HRID 65802

반응식

HRID 65802 반응식
O[CH:2]([CH3:6])[CH2:3][CH:4]=[O:5].[CH2:7]([C:9]([CH2:11]C)=O)[CH3:8].[CH:13](O)(C)C.[OH-].[Na+]>C(O)(=O)C>[CH3:13][C:3]1[C:4](=[O:5])[CH:7]([CH3:8])[CH:9]([CH3:11])[CH2:6][CH:2]=1

참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 7288Ethyl ketone2회HCID 78973-HydroxybutanalHCID 14798Sodium Hydroxide

생성물 1

HCID 892642-Cyclohexen-1-one, 2,5,6-trimethyl-수율 47.1%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 88 g of β-hydroxybutyraldehyde and 150 g of diethyl ketone is added dropwise in the course of one hour to a mixture of 250 g of diethyl ketone, 80 g of isopropanol and 5 g of sodium hydroxide powder which is boiling under reflux. The whole is boiled for another hour under reflux. Neutralization is effected with glacial acetic acid and the aqueous phase is separated. The organic layer is fractionated. 65 g of 2,5,6-trimethyl-2-cyclohexen-1-one having a boiling point of 74° to 76° C. at 12 mm Hg is obtained. The yield is 47% with reference to β-hydroxybutyraldehyde.

후처리

  1. temperatureunder reflux
  2. waitThe whole is boiled for another hour
  3. temperatureunder reflux
  4. customthe aqueous phase is separated

출처 및 근거

ORD 기록
ord-c16defd56be34a8fba979fa521f18f93
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04128728

연결된 노트

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