Glutaric Acid → HCID 178484388, 화합물
반응식
[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[OH-].[Na+].[C:12]([OH:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([OH:18])=[O:17].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:12]([O-:20])(=[O:19])[CH2:13][CH2:14][CH2:15][C:16]([O-:18])=[O:17]참가 물질
6
실험 절차
10.0 g of metformin, 2.40 g of sodium hydroxide and 3.98 g of glutaric acid were stirred in 150 ml of ethyl alcohol at a temperature of 70° C., and then methylene chloride was added thereto. The produced inorganic salt was filtered and ethyl acetate was added to the filtered solution. The produced crystal was filtered and dried in hot air, thus obtaining 6.79 g (yield: 57.7%) of metformin glutarate.
후처리
- filtrationThe produced inorganic salt was filtered
- additionethyl acetate was added to the filtered solution
- filtrationThe produced crystal was filtered
- customdried in hot air
출처 및 근거
- ORD 기록
- ord-ecf0fa3b2337412185e3c44166b38cbb
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076377B2
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