Adipic Acid → HCID 178484387, 화합물
반응식
[CH3:1][N:2]([C:4]([N:6]=[C:7]([NH2:9])[NH2:8])=[NH:5])[CH3:3].Cl.[OH-].[Na+].[C:13]([OH:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([OH:20])=[O:19].C(Cl)Cl>C(O)C>[CH3:1][N:2]([C:4]([NH:6][C:7]([NH2:9])=[NH:8])=[NH:5])[CH3:3].[C:13]([O-:22])(=[O:21])[CH2:14][CH2:15][CH2:16][CH2:17][C:18]([O-:20])=[O:19]참가 물질
6
실험 절차
10.00 g of metformin hydrochloride, 2.40 g of sodium hydroxide and 2.20 g of adipic acid were stirred in 150 ml of ethyl alcohol at 70° C., and then methylene chloride was added thereto. Then, the produced inorganic salt was filtered, and ethyl acetate was added to the filtrate. The produced crystal was filtered and dried in hot air, thus obtaining 4.90 g (yield: 80.5%) of metformin adipate.
후처리
- filtrationThen, the produced inorganic salt was filtered
- additionethyl acetate was added to the filtrate
- filtrationThe produced crystal was filtered
- customdried in hot air
출처 및 근거
- ORD 기록
- ord-6a57b952a08b47e2ab3e40695d305e26
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08076377B2
반응 노트
불러오는 중…