1-(1H-imidazole-1-carboximidoyl)-1H-imidazole → [4-(5-Amino-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine

HRID 658363노트

반응식

HRID 658363 반응식
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:19]=[N:18][CH:17]=[CH:16][C:11]=1[C:12]([NH:14][NH2:15])=[O:13].[N:20]1(C(=N)N2C=CN=C2)C=CN=[CH:21]1>CS(C)=O>[NH2:20][C:21]1[O:13][C:12]([C:11]2[CH:16]=[CH:17][N:18]=[CH:19][C:10]=2[NH:9][C:3]2[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=2[F:1])=[N:14][N:15]=1

참가 물질

4

반응물 2

HCID 113556541-(1H-imidazole-1-carboximidoyl)-1H-imidazoleHCID 115888023-[(2-Fluoro-4-iodophenyl)amino]isonicotinohydrazide

생성물 1

HCID 17747573[4-(5-Amino-[1,3,4]oxadiazol-2-yl)-pyridin-3-yl]-(2-fluoro-4-iodo-phenyl)-amine

시약·촉매·용매 1

HCID 679Dimethyl Sulfoxide용매

실험 절차

To a solution of 3-(2-Fluoro-4-iodo-phenylamino)-isonicotinic acid hydrazide (1 g, 2.68 mmol) in DMSO (6 mL) were added 1,1-di-1H-imidazol-1-yl-methyleneamine (864 mg, 5.36 mmol). The reaction mixture was stirred at RT for 18 h. Quenching of the reaction by adding water (60 mL). A solid precipitated out. The solid was filtered, washed with water and cold methanol. Yield: white solid 1.0 g. LC-MS (Method A) [4.66 min; 398(M+1)].

후처리

  1. customQuenching of the reaction
  2. additionby adding water (60 mL)
  3. customA solid precipitated out
  4. filtrationThe solid was filtered
  5. washwashed with water and cold methanol
  6. customLC-MS (Method A) [4.66 min; 398(M+1)]

출처 및 근거

ORD 기록
ord-7a28ea4cd7e24d478c5dcd4e04b62212
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076486B2

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