Potassium Hydroxide → 4-(Benzyloxy)benzoic acid
반응식
[OH-].[K+].[CH2:3]([O:10][C:11]1[CH:21]=[CH:20][C:14]([C:15]([O:17]CC)=[O:16])=[CH:13][CH:12]=1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO>[CH2:3]([O:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]([OH:17])=[O:16])=[CH:20][CH:21]=1)[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1참가 물질
4
실험 절차
To the solution of 0.5 g KOH in 40 ml MeOH, was added 6.5 mmol of ethyl 4-benzyloxybenzoate. After the resulting mixture was refluxed for 4 hrs, the excess methanol was removed. The residue was mixed with 30 ml water and extracted with ether twice. The water solution was acidified with conc. HCl and extracted with ethyl acetate. The ethyl acetate solution was washed with brine and dried. After evaporation of solvent, pure product was obtained in quantitative yield.
후처리
- temperatureAfter the resulting mixture was refluxed for 4 hrs
- customthe excess methanol was removed
- additionThe residue was mixed with 30 ml water
- extractionextracted with ether twice
- extractionextracted with ethyl acetate
- washThe ethyl acetate solution was washed with brine
- customdried
- customAfter evaporation of solvent
- custompure product was obtained in quantitative yield
출처 및 근거
- ORD 기록
- ord-e893d8e4b615491698f2580374c37cef
- 출처 데이터셋
- uspto-grants-2006_08
- 특허 번호
- US07083832B2
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