(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate → 4-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

HRID 6587

반응식

HRID 6587 반응식
C([O:8][C:9]1[CH:28]=[CH:27][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:26])([F:25])[F:24])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:11][CH:10]=1)C1C=CC=CC=1>C(OCC)(=O)C>[OH:8][C:9]1[CH:10]=[CH:11][C:12]([C:13]([O:15][C@@H:16]([C:23]([F:24])([F:25])[F:26])[CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH3:22])=[O:14])=[CH:27][CH:28]=1

참가 물질

3

반응물 1

HCID 22850730(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate

생성물 1

HCID 145492174-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester수율 99%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2.2 g of [R]-1-trifluoromethylheptyl 4-benzyloxybenzoate, (13) 100 mg of PdOH/C in 50 ml of ethyl acetate was stirred at RT over night under H2 atmosphere. Then the catalyst was filtered out and filtrate was evaporated to dryness to give the pure compound in yield of 99%.

후처리

  1. filtrationThen the catalyst was filtered out
  2. customfiltrate was evaporated to dryness
  3. customto give the pure compound in yield of 99%

출처 및 근거

ORD 기록
ord-3687b0a5c976428fb52ff00b4203cdb7
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07083832B2

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