Ethyl 1-aminocyclopropane-1-carboxylate hydrochloride → Ethyl 1-(3-(tert-butyldimethylsilyloxy)benzylamino)-cyclopropanecarboxylate

HRID 658776

반응식

HRID 658776 반응식
[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH:12]=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].Cl.[NH2:18][C:19]1([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:21][CH2:20]1>>[Si:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][NH:18][C:19]1([C:22]([O:24][CH2:25][CH3:26])=[O:23])[CH2:21][CH2:20]1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 386203Ethyl 1-aminocyclopropane-1-carboxylate hydrochlorideHCID 112071113-(t-Butyldimethylsilyloxy)benzaldehyde

생성물 1

HCID 59524373Ethyl 1-(3-(tert-butyldimethylsilyloxy)benzylamino)-cyclopropanecarboxylate수율 87%

실험 절차

Prepared as in Example 12-1b from 3-(tert-butyldimethylsilyloxy)benzaldehyde (Example 12-1c) and ethyl 1-aminocyclopropanecarboxylate hydrochloride. Yield 87%, colorless liquid. MS 350 (MH+).

출처 및 근거

ORD 기록
ord-13c7b07b03504482a2d5d68005edf232
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08076491B2

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