Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Hydroxide → 5-Benzoylfuran-2-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | 5-Benzoyl-furan-2-carboxylic acid methyl ester | HCID 10775790 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-Benzoylfuran-2-carboxylic acid | HCID 2877255 | — |
반응 단계
The crude ester (8) (80 mg, 0.35 mmol) was hydrolysed using Method C, except that MeOH (0.8 mL) and 1 M NaOH (0.8 mL) were used. After the reaction, the solvent was removed under a stream of nitrogen gas, acidified using 1N HCl, extracted with EtOAc, dried (MgSO4), filtered and the solvent concentrated in vacuo to give the crude title compound. Yield: 48 mg; HPLC Purity: >66%; LC tr 0.09 min
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08080567B2 |
| 출처 데이터셋 | uspto-grants-2011_12 |
| ORD ID | ord-24296fc598344a6baed41b0f03dc3459 |
| 출처 메모 | uspto-grants-2011_12 |