Sodium Hydroxide → 5-Phenylfuran-2-carboxylic acid

HRID 659114

반응식

HRID 659114 반응식
[C:1]1([C:7]2[O:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-:14].[Na+]>[N+]([O-])([O-])=O.[Ag+]>[C:1]1([C:7]2[O:11][C:10]([C:12]([OH:14])=[O:13])=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 14798Sodium Hydroxide2회HCID 27694205-Phenyl-2-furaldehyde

생성물 1

HCID 7362555-Phenylfuran-2-carboxylic acid

시약·촉매·용매 1

HCID 24470Silver Nitrate촉매

반응 조건

온도
60 °C

실험 절차

To 5-phenyl-2-furaldehyde (35) (690 mg, 4.01 mmol) was added solid NaOH (176 mg, 4.40 mmol) then 10% NaOH solution (6.2 mL). Silver nitrate (680 mg, 4.00 mmol) was added and the reaction mixture heated to 60° C. for 4.5 hours then cooled to ambient temperature. The reaction mixture was then filtered and washed with water. The filtrate was acidified to pH 2 using 2N HCl and the precipitated product filtered and dried to give the title compound.

후처리

  1. temperaturethen cooled to ambient temperature
  2. filtrationThe reaction mixture was then filtered
  3. washwashed with water
  4. filtrationthe precipitated product filtered
  5. customdried

출처 및 근거

ORD 기록
ord-fe5a9621d48b45708e5f897cbdb23907
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080567B2

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