Acetic Anhydride → Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 3,5,7-trimethyl-

반응식

[CH3:1][N:2]1[C:9]([NH:10][OH:11])=[CH:8][C:6](=[O:7])[N:5]([CH3:12])[C:3]1=[O:4].[C:13](OC(=O)C)(=O)[CH3:14]>>[CH3:13][C:14]1[O:11][N:10]=[C:9]2[C:8]=1[C:6](=[O:7])[N:5]([CH3:12])[C:3](=[O:4])[N:2]2[CH3:1]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 27859331,3-Dimethyl-6-hydroxylaminouracil

생성물 1

HCID 100470Isoxazolo(3,4-d)pyrimidine-4,6(5H,7H)-dione, 3,5,7-trimethyl-

실험 절차

One gram of 1,3-dimethyl-6-hydroxyaminouracil is boiled with 10 ml of acetic anhydride at 140° C. for 1 hour and, when hot, the insolubles are filtered off. The filtrate is concentrated to dryness to recover 0.7 g of the captioned compound as colorless needles. As recrystallized from ethanol, the compound melts at 200°-202° C.

후처리

filtrationwhen hot, the insolubles are filtered off
concentrationThe filtrate is concentrated to dryness
customto recover 0.7 g of the captioned compound as colorless needles
customAs recrystallized from ethanol

출처 및 근거

ORD 기록: ord-325744882a9341599ac683156f0a193a
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04129654

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