Hydrochloric Acid → cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride

HRID 659183

반응식

HRID 659183 반응식
C(OC(=O)[NH:7][C@@H:8]1[CH2:13][CH2:12][CH2:11][CH2:10][C@@H:9]1[N:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1)(C)(C)C.[ClH:20]>O1CCOCC1>[ClH:20].[ClH:20].[N:14]1([C@H:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C@H:8]2[NH2:7])[CH2:15][CH2:16][CH2:17][CH2:18]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66680888cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester

생성물 1

HCID 66680564cis-2-Pyrrolidin-1-yl-cyclohexylamine dihydrochloride수율 85%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

cis-(2-Pyrrolidin-1-yl-cyclohexyl)-carbamic acid tert-butyl ester (1.8 g, 6.7 mmol) was dissolved in dioxane. 4H HCl in dioxane (17 mL, 67 mmol) were added and the reaction mixture was stirred at room temperature overnight. The solvent was evaporated off. The residue was crystallized with ethanol and yielded cis-2-pyrrolidin-1-yl-cyclohexylamine dihydrochloride as a white solid (1.37 g, 85%), MS: m/e=169.2 [(M+H)+].

후처리

  1. customThe solvent was evaporated off
  2. customThe residue was crystallized with ethanol

출처 및 근거

ORD 기록
ord-9401b56faf364cf2a2ea9ceacfb9a450
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080541B2

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