Hydrochloric Acid → 2-Cyclopropyl-4,6-bis-trifluoromethyl-benzaldehyde

HRID 659216

반응식

HRID 659216 반응식
C(N=[CH:6][C:7]1[C:12]([C:13]([F:16])([F:15])[F:14])=[CH:11][C:10]([C:17]([F:20])([F:19])[F:18])=[CH:9][C:8]=1[CH:21]1[CH2:23][CH2:22]1)CCC.Cl.[OH2:25]>>[CH:21]1([C:8]2[CH:9]=[C:10]([C:17]([F:20])([F:19])[F:18])[CH:11]=[C:12]([C:13]([F:16])([F:15])[F:14])[C:7]=2[CH:6]=[O:25])[CH2:23][CH2:22]1

참가 물질

4

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 58167766Butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine

생성물 1

HCID 581677622-Cyclopropyl-4,6-bis-trifluoromethyl-benzaldehyde

실험 절차

Crude butyl-[1-(2-cyclopropyl-4,6-bis-trifluoromethyl-phenyl)-methylidene]-amine (intermediate AL, 3.54 g, 10.5 mmol) was dissolved in 8 mL water. Hydrochloric acid (25%, 0.49 mL) was added and the mixture was refluxed for 2 h. The mixture was extracted three times with ethyl acetate. The combined organic phases were dried on sodium sulfate, filtered and evaporated. The crude material, brown oil (1.01 g, 34%) was used without further purification.

후처리

  1. temperaturethe mixture was refluxed for 2 h
  2. extractionThe mixture was extracted three times with ethyl acetate
  3. customThe combined organic phases were dried on sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customThe crude material, brown oil (1.01 g, 34%) was used without further purification

출처 및 근거

ORD 기록
ord-d55d465d5fcc4d03b6c114a5eb9e903d
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080541B2

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