Methyl 2-iodo-4-(trifluoromethyl)benzoate → 2-Cyclobutyl-4-trifluoromethyl-benzoic acid

HRID 659219

반응식

HRID 659219 반응식
[CH:1]1([C:4]2[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[CH:10]=[CH:9][C:5]=2[C:6]([OH:8])=[O:7])[CH2:3][CH2:2]1.[CH3:17]OC(=O)C1C=CC(C(F)(F)F)=CC=1I.[Br-].C1([Zn+])CCC1>>[CH:1]1([C:4]2[CH:12]=[C:11]([C:13]([F:14])([F:15])[F:16])[CH:10]=[CH:9][C:5]=2[C:6]([OH:8])=[O:7])[CH2:3][CH2:2][CH2:17]1

참가 물질

4

반응물 3

HCID 59438424Methyl 2-iodo-4-(trifluoromethyl)benzoateHCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acidHCID 178419766HCID 178419766, 화합물

생성물 1

HCID 594384322-Cyclobutyl-4-trifluoromethyl-benzoic acid

실험 절차

The title compound, white solid, MS: m/e=243.0 [(M−H)−], was prepared in accordance with the general method of intermediate K from 2-iodo-4-trifluoromethyl-benzoic acid methyl Ester and cyclobutylzincbromide followed by saponification with sodium hydroxide.

출처 및 근거

ORD 기록
ord-459820a8946d40eab6c887b0d71dd365
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080541B2

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