Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate → 2-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65922노트

반응식

HRID 65922 반응식
[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[N:11]=[CH:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]>CO.O=[Pt]=O>[C:1]([C:6]1[CH:7]=[C:8]2[C:17]3[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=3[NH:11][CH2:10][N:9]2[CH:18]=1)([O:3][CH2:4][CH3:5])=[O:2]

참가 물질

4

반응물 1

HCID 4407258Ethyl pyrrolo[1,2-c]quinazoline-2-carboxylate

생성물 1

HCID 227563502-Carbethoxy-5,6-dihydropyrrolo[1,2-c]quinazoline

시약·촉매·용매 2

HCID 345198Adams' catalyst촉매HCID 887Methanol용매

실험 절차

The product of Example II (2.5 g, 0.01 m) was dissolved in MeOH (250 ml). The catalyst, PtO2 (0.5 g), was added and the mixture was hydrogenated at 42 p.s.i. for 3 hrs. Filtration and removal of the solvent in vacuo yielded a white solid. Crystallization from MeOH afforded the product as a white solid; m.p. 140°-141° C.

후처리

  1. filtrationFiltration and removal of the solvent in vacuo
  2. customyielded a white solid
  3. customCrystallization from MeOH

출처 및 근거

ORD 기록
ord-d50ec719b5ab40d785f03502f8272481
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129653

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