Water → 6-(3-Hydroxypropyl)-2-methyl-5,6-dihydropyrrolo[1,2-c]quinazoline

HRID 65928노트

반응식

HRID 65928 반응식
[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH3:7][C:8]1[CH:9]=[C:10]2[C:19]3[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=3[N:13]([CH2:20][CH2:21][C:22](OC)=[O:23])[C:12](=O)[N:11]2[CH:27]=1.O.[OH-].[Na+]>CCOCC>[OH:23][CH2:22][CH2:21][CH2:20][N:13]1[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][C:19]=2[C:10]2=[CH:9][C:8]([CH3:7])=[CH:27][N:11]2[CH2:12]1

참가 물질

6

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 21226445Aluminium lithium hydrideHCID 227563572-Methyl-6-(beta-carbomethoxyethyl)pyrrolo[1,2-c]quinazolin-5-one

생성물 1

HCID 227563636-(3-Hydroxypropyl)-2-methyl-5,6-dihydropyrrolo[1,2-c]quinazoline

시약·촉매·용매 1

HCID 3283Diethyl Ether용매2회

실험 절차

LiAlH4 (2.88 g, 0.076 m) was slurried in ether (250 ml) and to this was added a solution of the product of Example XXXV (5.5 g, 0.019 m) in ether (100 ml). The reaction mixture was stirred at ambient temperature for 1/2 hr. To the reaction mixture was added dropwise and successively H2O (3.0 ml), NaOH (3.0 ml of 15% aqueous), and H2O (9.0 ml). The resulting precipitate was filtered and washed with ether. The solvent was removed in vacuo from the filtrate and the residue crystallized from pentane to yield the desired product as a pale yellow solid; m.p. 77°-78° C.

후처리

  1. additionTo the reaction mixture was added dropwise
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with ether
  4. customThe solvent was removed in vacuo from the filtrate
  5. customthe residue crystallized from pentane

출처 및 근거

ORD 기록
ord-b6102c0ae1624cf5b385ea293eb4eb34
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04129653

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