Dichloromethane → 2-(1-Bromoethyl)-3-chloro-1,4-difluorobenzene

HRID 659314노트

반응식

HRID 659314 반응식
P(Br)(Br)[Br:2].C(Cl)Cl.[Cl:8][C:9]1[C:14]([F:15])=[CH:13][CH:12]=[C:11]([F:16])[C:10]=1[CH:17](O)[CH3:18]>O>[Br:2][CH:17]([C:10]1[C:9]([Cl:8])=[C:14]([F:15])[CH:13]=[CH:12][C:11]=1[F:16])[CH3:18]

참가 물질

5

반응물 3

HCID 6344Dichloromethane2회HCID 24614Phosphorus tribromideHCID 211113742-Chloro-3,6-difluoro-α-methylbenzenemethanol

생성물 1

HCID 578860042-(1-Bromoethyl)-3-chloro-1,4-difluorobenzene수율 78%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Phosphorus tribromide (1.3 mL) and anhydrous CH2Cl2 (50 mL) were combined and then cooled over ice water for 20 minutes. The cooled solution was then added to a mixture of 1-(2-chloro-3,6-difluorophenyl)ethanol (2.71 g) and methylene chloride (50 mL), and the resulting mixture was stirred at room temperature for two (2) hours. The mixture was then poured into H2O and extracted into CH2Cl2. The organic phase was isolated, dried with magnesium sulfate, filtered, and concentrated to give the title compound (78% yield).

후처리

  1. extractionextracted into CH2Cl2
  2. customThe organic phase was isolated
  3. dry with materialdried with magnesium sulfate
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-927ec4335dd24913b359c537d8314ebb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080561B2

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