Hydrochloric Acid → 3-(1H-1,2,3-triazol-1-yl)piperidine hydrochloride

HRID 659625

반응식

HRID 659625 반응식
[N:1]1([CH:6]2[CH2:11][CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]2)[CH:5]=[CH:4][N:3]=[N:2]1.[ClH:19]>CO>[ClH:19].[N:1]1([CH:6]2[CH2:11][CH2:10][CH2:9][NH:8][CH2:7]2)[CH:5]=[CH:4][N:3]=[N:2]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 19005952Tert-butyl 3-(1H-1,2,3-triazol-1-YL)piperidine-1-carboxylate

생성물 1

HCID 190059273-(1H-1,2,3-triazol-1-yl)piperidine hydrochloride

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
30 °C

실험 절차

A 100-mL round-bottomed flask was charged with a solution of tert-butyl 3-(1H-1,2,3-triazol-1-yl)piperidine-1-carboxylate (2.8 g, 11.11 mmol, 1.00 equiv) in MeOH (50 mL). To this mixture was added conc. HCl (10 mL). The resulting solution was stirred at 30° C. for 5 hours in an oil bath. Upon completion, the resulting mixture was cooled down to room temperature and concentrated on a rotary evaporator affording 3-(1H-1,2,3-triazol-1-yl)piperidine hydrochloride as pale yellow solid (3 g).

후처리

  1. temperatureUpon completion, the resulting mixture was cooled down to room temperature
  2. concentrationconcentrated on a rotary evaporator

출처 및 근거

ORD 기록
ord-bc852a0ebd4e4489a5648007dbcfc97b
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080566B1

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