Triphenylphosphine → 9H-carbazole-4-carbaldehyde

HRID 659655노트

반응식

HRID 659655 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([CH:16]=[O:17])[C:9]=1[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([O-])=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1>ClC1C=CC=CC=1Cl>[CH:5]1[C:4]2[NH:1][C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[C:9]=2[C:8]([CH:16]=[O:17])=[CH:7][CH:6]=1

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 541378936-Nitrobiphenyl-2-carbaldehyde

생성물 1

HCID 200308319H-carbazole-4-carbaldehyde수율 56.3%

시약·촉매·용매 1

HCID 72391,2-Dichlorobenzene용매

실험 절차

A 100-mL round-bottom flask was placed a solution of 6-nitrobiphenyl-2-carbaldehyde (6.2 g, 27.31 mmol, 1.00 equiv) in 1,2-dichlorobenzene (60 mL). To the mixture was added PPh3 (17.9 g, 68.32 mmol, 2.50 equiv) and the mixture was heated to reflux for 30 hours. Upon completion, the resulting mixture was concentrated on a rotary evaporator to give a residue that was purified by silica gel column chromatography affording 9H-carbazole-4-carbaldehyde as yellow solid (3 g, 56%).

후처리

  1. customA 100-mL round-bottom flask was placed
  2. temperaturethe mixture was heated
  3. temperatureto reflux for 30 hours
  4. concentrationUpon completion, the resulting mixture was concentrated on a rotary evaporator
  5. customto give a residue that
  6. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-d633bdda07084425ae5b2cbab783e3e4
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080566B1

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