Hydrochloric Acid → HCID 178488023, 화합물

HRID 659825노트

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HRID 659825 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[N:9]=[C:8]([OH:13])[C:7](O)=[N:6]2.O=S(Cl)[Cl:17].Cl>CN(C=O)C>[Cl:17][C:7]1[C:8]([OH:13])=[N:9][C:10]2[C:5]([N:6]=1)=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 24386Thionyl ChlorideHCID 178488026HCID 178488026, 화합물

생성물 1

HCID 178488023HCID 178488023, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
110 °C

실험 절차

A solution (1.53 M) of 6-methoxyquinoxaline-2,3-diol in DMF was treated with SOCl2 (1 eq) and heated at 110° C. After 1.5 h, the reaction mixture was cooled and poured into aqueous HCl (1 N). The resulting precipitate was filtered and washed with H2O and Et2O. The dried solid contained predominantly the title compound as a mixture with 6-methoxyquinoxaline-2,3-diol and 2,3-dichloro-6-methoxyquinoxaline. This material was used directly in the subsequent step. MS (ES+) m/z 211 (M+H)+

후처리

  1. temperaturethe reaction mixture was cooled
  2. filtrationThe resulting precipitate was filtered
  3. washwashed with H2O and Et2O

출처 및 근거

ORD 기록
ord-f68c3efe021647389423858c30b425de
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08080654B2

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