Nitric Acid → 4-amino-3-nitrophenylPropanoic acid

HRID 660278

반응식

HRID 660278 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:4][CH:3]=1.[N+:13]([O-])([OH:15])=[O:14].O>CC(O)=O>[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([CH3:12])[C:9]([OH:11])=[O:10])=[CH:6][C:7]=1[N+:13]([O-:15])=[O:14]

참가 물질

5

반응물 3

HCID 944Nitric AcidHCID 962WaterHCID 430264-Aminohydratropic acid

생성물 1

HCID 122268174-amino-3-nitrophenylPropanoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A solution of 2-(4-Aminophenyl)propanoic acid (8.45 g, 51.2 mmol) in AcOH (70 mL) was added HNO3 (60%, 5.66 g) at room temperature. The reaction mixture was refluxed for 4 hrs then cooled to room temperature. The mixture was poured into iced water (200 mL), and extracted with CH2Cl2. The organic layer was dried over MgSO4, filtered, and concentrated in vacuo.

후처리

  1. temperatureThe reaction mixture was refluxed for 4 hrs
  2. extractionextracted with CH2Cl2
  3. dry with materialThe organic layer was dried over MgSO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-19d595998b3a4f71862231140536bfd5
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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