2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid
반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1참가 물질
5
실험 절차
To a stirred solution of 2-(4-nitrophenyl)propionic acid (2.05 g) in THF (20 mL) and EtOH (20 mL) was slowly added 10% Pd/C (0.21 g) at room temperature. After hydrogenated for 2 h with H2 balloon, the reaction mixture was filtered through celite pad and washed with EtOH. The filtrate was concentrated in vacuo to afford the product as pale brown solid. (1.75 g, quantitative)
후처리
- customat room temperature
- filtrationthe reaction mixture was filtered through celite pad
- washwashed with EtOH
- concentrationThe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-ae78d0401a8b4ca7a923ce6f9ad8b273
- 출처 데이터셋
- uspto-grants-2011_12
- 특허 번호
- US08084484B2
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