2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

HRID 660330

반응식

HRID 660330 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1

참가 물질

5

반응물 1

HCID 892442-(4-Nitrophenyl)propionic acid

생성물 1

HCID 430264-Aminohydratropic acid

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

To a stirred solution of 2-(4-nitrophenyl)propionic acid (2.05 g) in THF (20 mL) and EtOH (20 mL) was slowly added 10% Pd/C (0.21 g) at room temperature. After hydrogenated for 2 h with H2 balloon, the reaction mixture was filtered through celite pad and washed with EtOH. The filtrate was concentrated in vacuo to afford the product as pale brown solid. (1.75 g, quantitative)

후처리

  1. customat room temperature
  2. filtrationthe reaction mixture was filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ae78d0401a8b4ca7a923ce6f9ad8b273
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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