2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

HRID 660342

반응식

HRID 660342 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1

참가 물질

5

반응물 1

HCID 892442-(4-Nitrophenyl)propionic acid

생성물 1

HCID 430264-Aminohydratropic acid

시약·촉매·용매 3

HCID 23938Palladium촉매HCID 702Ethanol용매HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.

후처리

  1. customat room temperature
  2. filtrationThe mixture is filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate is concentrated in vacuo

출처 및 근거

ORD 기록
ord-fdc8fedb933d421686298bc443ce1c81
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

연결된 노트

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