Hydrochloric Acid → 2-(2-Methanesulfonylamino-benzothiazole-6-yl)-propionic acid ethyl ester

HRID 660346노트

반응식

HRID 660346 반응식
[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([NH2:14])[S:13][C:9]=2[CH:8]=1)[CH3:6])[CH3:2].[CH3:18][S:19](Cl)(=[O:21])=[O:20].Cl>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:17])[CH:5]([C:7]1[CH:16]=[CH:15][C:10]2[N:11]=[C:12]([NH:14][S:19]([CH3:18])(=[O:21])=[O:20])[S:13][C:9]=2[CH:8]=1)[CH3:6])[CH3:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31297Methanesulfonyl chlorideHCID 13477940Ethyl 2-amino-alpha-methylbenzothiazole-6-acetate

생성물 1

HCID 577421492-(2-Methanesulfonylamino-benzothiazole-6-yl)-propionic acid ethyl ester

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

A mixture of 4 (347 mg, 1 mmol) in pyridine (3 ml) is added to MsCl (0.13 ml, 1.21 mmol) at room temperature. The reaction mixture is stirred for 14 h at room temperature. 1 N HCl (30 ml) is added to the mixture. The mixture extracted with ethyl acetate. The organic layer is dried over magnesium sulfate. The filtrate was concentrated in vacuo. The residue was purified by flash column chromatography (n-Hexane:EtOAc).

후처리

  1. extractionThe mixture extracted with ethyl acetate
  2. dry with materialThe organic layer is dried over magnesium sulfate
  3. concentrationThe filtrate was concentrated in vacuo
  4. customThe residue was purified by flash column chromatography (n-Hexane:EtOAc)

출처 및 근거

ORD 기록
ord-ff786c1545fb463bb074054f0acefcdb
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084484B2

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