cis-4-Acetyl-2-oxa-4-aza-bicyclo-[4.3.0]non-7-en-3-one → cis-4-Acetyl-2-oxa-4-aza-bicyclo[4.3.0]nonan-3-one
반응식
[C:1]([N:4]1[CH2:12][C@@H:11]2[C@@H:7]([CH2:8][CH:9]=[CH:10]2)[O:6][C:5]1=[O:13])(=[O:3])[CH3:2]>CO.[Pt](=O)=O>[C:1]([N:4]1[CH2:12][C@@H:11]2[C@@H:7]([CH2:8][CH2:9][CH2:10]2)[O:6][C:5]1=[O:13])(=[O:3])[CH3:2]참가 물질
4
실험 절차
181 g (1.0 mol) of cis-4-acetyl-2-oxa-4-aza-bicyclo-[4.3.0]non-7-en-3-one, in 1,000 ml of methanol, are hydrogenated at 25° C. under normal pressure in the presence of platinum dioxide. After the catalyst has been filtered off, the reaction solution is freed from the solvent by distillation. Distillation of the residue gives 183 g (100% of theory) of cis-4-acetyl-2-oxa-4-aza-bicyclo[4.3.0]nonan-3-one (melting point: 80°-83° C.; from methanol).
후처리
- filtrationAfter the catalyst has been filtered off
- distillationthe reaction solution is freed from the solvent by distillation
- distillationDistillation of the residue
출처 및 근거
- ORD 기록
- ord-1e93781ef9fc4de5b719cb817a928260
- 출처 데이터셋
- uspto-grants-1978_12
- 특허 번호
- US04130563
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