Stannous Chloride → 2-(Benzyloxy)-4-fluoroaniline

HRID 660827노트

반응식

HRID 660827 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[N+:16]([O-])=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[Sn]Cl>CCO>[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([F:15])[CH:12]=[CH:11][C:10]=1[NH2:16])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 110969082-(Benzyloxy)-4-fluoro-1-nitrobenzene

생성물 1

HCID 167713362-(Benzyloxy)-4-fluoroaniline

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a stirred solution of 2-benzyloxy-4-fluoro-1-nitrobenzene (2.4 g, 10 mmol) in EtOH (20 mL) is added SnCl2 (9.45 g, 50 mmol) and the suspension is stirred at RT overnight. The solvent is removed under reduced pressure and the residue is adjusted to pH >8. The aqueous layer is extracted with EtOAc and the combined organic layers are washed with water and brine, then dried over MgSO4 and filtered. The solvent is removed under reduced pressure to give the product as a red oil.

후처리

  1. customThe solvent is removed under reduced pressure
  2. extractionThe aqueous layer is extracted with EtOAc
  3. washthe combined organic layers are washed with water and brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. customThe solvent is removed under reduced pressure

출처 및 근거

ORD 기록
ord-75440715f8304066b8180cb26d54d7b4
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084448B2

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