Hydrochloric Acid → [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

HRID 660875노트

반응식

HRID 660875 반응식
C([O:3][C:4](=[O:22])[CH2:5][N:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][C:14]([Br:17])=[CH:13][CH:12]=2)[N:8]([CH:18]2[CH2:20][CH2:19]2)[C:7]1=[O:21])C.[OH-].[K+].Cl>CO>[Br:17][C:14]1[CH:15]=[CH:16][C:11]([C:9]2[N:8]([CH:18]3[CH2:20][CH2:19]3)[C:7](=[O:21])[N:6]([CH2:5][C:4]([OH:22])=[O:3])[CH:10]=2)=[CH:12][CH:13]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 58012242Ethyl [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate

생성물 1

HCID 58011674[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

502 mg (1.28 mmol) of ethyl[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 124A are placed in 0.94 ml methanol, treated with 0.34 ml 20% aqueous potassium hydroxide and stirred overnight at room temperature. It is adjusted to pH 3 with 1 N hydrochloric acid, the resulting precipitate recovered by filtration, and the product washed with water and dried in vacuo. 369 mg (80% of theory) of the target compound, which is reacted without further purification, are thus obtained.

후처리

  1. filtrationthe resulting precipitate recovered by filtration
  2. washthe product washed with water
  3. customdried in vacuo
  4. custom369 mg (80% of theory) of the target compound, which is reacted without further purification
  5. customare thus obtained

출처 및 근거

ORD 기록
ord-99b319155a4349a5a56dc243f5c647cf
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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