1-Hydroxybenzotriazole → HCID 58012213, 화합물

HRID 660934

반응식

HRID 660934 반응식
[CH:1]1([N:4]2[C:8]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)=[CH:7][N:6]([CH2:15][C:16]([OH:18])=O)[C:5]2=[O:19])[CH2:3][CH2:2]1.[CH:20]1[C:29]2[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:23]=[CH:22][C:21]=1[CH:30]([NH2:32])[CH3:31].CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1>CN(C=O)C>[CH:1]1([N:4]2[C:8]([C:9]3[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=3)=[CH:7][N:6]([CH2:15][C:16]([NH:32][CH:30]([C:21]3[CH:22]=[CH:23][C:24]4[C:29](=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH:20]=3)[CH3:31])=[O:18])[C:5]2=[O:19])[CH2:2][CH2:3]1

참가 물질

6

반응물 4

HCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 38571451-(Naphthalen-2-yl)ethan-1-amineHCID 58011929HCID 58011929, 화합물

생성물 1

HCID 58012213HCID 58012213, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

40 mg (0.155 mmol) of (3-cyclopropyl-2-oxo-4-phenyl-2,3-dihydro-1H-imidazol-1-yl)-acetic acid from Example 128A, 29.2 mg (0.17 mmol) of 1-(2-naphthyl)ethylamine, 38.6 mg (0.20 mmol) of EDC hydrochloride and 25.1 mg (0.19 mmol) of HOBt are dissolved in 1.5 ml of dry DMF and stirred overnight at RT. The crude product is purified by preparative HPLC [Method 10, with addition of 0.01 M hydrochloric acid in the water]. The target compound is obtained in a yield of 41 mg (63% of theory).

후처리

  1. customThe crude product is purified by preparative HPLC [Method 10
  2. additionwith addition of 0.01 M hydrochloric acid in the water]
  3. customThe target compound is obtained in a yield of 41 mg (63% of theory)

출처 및 근거

ORD 기록
ord-2be96ec387e743edbb9035ea628c9eb1
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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