Methane → 4,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

HRID 66148노트

반응식

HRID 66148 반응식
C([O:3][C:4]([C:6]1[N:11](CCC)[C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]=2[C:8](=[O:25])[CH:7]=1)=[O:5])C.Cl.C>>[O:25]=[C:8]1[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[NH:11][C:10]2[CH:15]=[CH:16][C:17](=[O:24])[C:18]([O:20][CH2:21][CH2:22][CH3:23])=[CH:19][C:9]1=2

참가 물질

4

반응물 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 53707130HCID 53707130, 화합물

생성물 1

HCID 227556674,7-Dihydro-4,7-dioxo-6-propoxy-1H-cyclohepta[b]pyridine-2-carboxylic acid

실험 절차

A mixture of 4,7-dihydro-4,7-dioxo-6-propoxy-1-propyl-1H-cyclohepta[b]pyridine-2-carboxlic acid ethyl ester (3.8 g, described in Example 22) and 19% hydrochloric acid (113 ml) is refluxed for 30 minutes. Charcoal is added and the hot mixture is filtered. The filtrate is cooled to room temperature and the crystalline precipitate is collected and dried to obtain the title compound, mp > 250° C.

후처리

  1. temperatureis refluxed for 30 minutes
  2. filtrationthe hot mixture is filtered
  3. customthe crystalline precipitate is collected
  4. customdried

출처 및 근거

ORD 기록
ord-768ff5e905c442d292fe4bdf6acf1096
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04130649

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