Hydrochloric Acid → 1-(2-Hydroxyethyl)-2,6-diethyl-2,3,6-trimethylpiperidine

HRID 66251노트

반응식

HRID 66251 반응식
[CH2:1]([C:3]1([CH3:13])[CH:8]([CH3:9])[CH2:7][CH2:6][C:5]([CH2:11][CH3:12])([CH3:10])[NH:4]1)[CH3:2].Cl.[CH2:15]1[O:17][CH2:16]1>CO>[OH:17][CH2:16][CH2:15][N:4]1[C:5]([CH2:11][CH3:12])([CH3:10])[CH2:6][CH2:7][CH:8]([CH3:9])[C:3]1([CH2:1][CH3:2])[CH3:13]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 6354Ethylene OxideHCID 205360782,6-Diethyl-2,3,6-trimethylpiperidine

생성물 1

HCID 227545711-(2-Hydroxyethyl)-2,6-diethyl-2,3,6-trimethylpiperidine

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
100 °C

실험 절차

An autoclave is filled with 36.6 g 2,6-diethyl-2,3,6-trimethylpiperidine, 150 ml of methanol and 1 ml conc. hydrochloric acid. 11 g of ethylene oxide are added under a pressure of 2 atmospheres and the autoclave is heated to 100° C. for 24 hours. The methanol is distilled off and the residue is purified by fractional distillation which yields 1-(2-hydroxyethyl)-2,6-diethyl-2,3,6-trimethylpiperidine (Compound No. 8) boiling at 106° C./0.1 mm Hg.

후처리

  1. distillationThe methanol is distilled off
  2. distillationthe residue is purified by fractional distillation which

출처 및 근거

ORD 기록
ord-6e1ea5acf66642c2ad3482a3db0c094a
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131599

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