Water → 2-Chloro-1-(2-methoxyphenyl)ethan-1-ol

HRID 66321노트

반응식

HRID 66321 반응식
CO[CH:3]([Cl:12])[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].O.[BH4-].[Na+].[O:16]1CCOC[CH2:17]1>>[Cl:12][CH2:3][CH:4]([OH:5])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][C:11]=1[O:16][CH3:17]

참가 물질

5

반응물 4

HCID 962WaterHCID 312751,4-DioxaneHCID 4311764Sodium borohydrideHCID 227549172-Methoxy-alpha-chloroacetophenone

생성물 1

HCID 224917592-Chloro-1-(2-methoxyphenyl)ethan-1-ol

실험 절차

1.7 g of 2-methoxy-α-chloroacetophenone are dissolved in 30 ml of dioxane, and 12 ml of water are added thereto. 600 mg of sodium borohydride are added gradually to the solution at 10° to 20° C. Then, the mixture is treated in the same manner as described in Example 2-(1). 1.4 g of α-chloromethyl-2-methoxybenzylalcohol are obtained as a crude oil.

후처리

  1. additionThen, the mixture is treated in the same manner

출처 및 근거

ORD 기록
ord-3f9bca722ccc4b99a3df1596ea863917
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131686

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