Sec-Butylamine → 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one

HRID 66333

반응식

HRID 66333 반응식
[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([N:12]3[CH:20]([O:21][C:22](OC4C=CC=CC=4)=[O:23])[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[C:13]3=[O:31])=[N:9]2)=[CH:4][CH:3]=1.[CH:32]([NH2:36])([CH2:34][CH3:35])[CH3:33]>C(OC(C)C)(C)C>[Cl:1][C:2]1[N:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([N:12]3[CH:20]([O:21][C:22]([NH:36][CH:32]([CH2:34][CH3:35])[CH3:33])=[O:23])[C:19]4[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=4)[C:13]3=[O:31])=[N:9]2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 24874Sec-ButylamineHCID 233436372-(7-Chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-1-isoindolinone

생성물 1

HCID 227547382-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one

시약·촉매·용매 1

HCID 7914Diisopropyl Ether용매

반응 조건

온도
65 °C

실험 절차

A mixture of 2-(7-chloro-1,8-naphthyridin-2-yl)-3-phenoxycarbonyloxy-isoindolin-1-one (8.6 g.) and sec-butylamine (40 cc.) is heated at 65° C. until dissolution. The reaction mixture is then diluted with diisopropyl ether (240 cc.). The precipitate formed is filtered off and recrystallised from acetonitrile (60 cc.). 2-(7-Chloro-1,8-naphthyridin-2-yl)-3-sec-butylaminocarbonyloxy-isoindolin-1-one (3 g.), melting at 220°-222° C., is thus obtained.

후처리

  1. customThe precipitate formed
  2. filtrationis filtered off
  3. customrecrystallised from acetonitrile (60 cc.)

출처 및 근거

ORD 기록
ord-023d2509928949a9bbadc17115bc650a
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131674

연결된 노트

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