Acetic Anhydride → 5-(Trifluoromethyl)isobenzofuran-1,3-dione

반응식

[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([C:12]([OH:14])=[O:13])[C:6](=[CH:10][CH:11]=1)[C:7](O)=[O:8].C(OC(=O)C)(=O)C>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]2[C:12](=[O:14])[O:13][C:7](=[O:8])[C:6]2=[CH:10][CH:11]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 5990394-(Trifluoromethyl)phthalic acid

생성물 1

HCID 127177895-(Trifluoromethyl)isobenzofuran-1,3-dione수율 74.7%

실험 절차

4-Trifluoromethylphthalic acid (106.6 g.) and acetic anhydride (215 cc.) are heated at the reflux temperature for 30 minutes. After concentrating the mixture under reduced pressure (30 mm.Hg), the residue is stirred with cyclohexane (420 cc.). After filtration and drying, 4-trifluoromethylphthalic anhydride (73.5 g.), melting at 54° C., is obtained.

후처리

concentrationAfter concentrating the mixture under reduced pressure (30 mm.Hg)
filtrationAfter filtration
customdrying

출처 및 근거

ORD 기록: ord-32b5d7c475b04f468a9c379ef539b463
출처 데이터셋: uspto-grants-1978_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04131674

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