Pyridine → N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

HRID 66356노트

반응식

HRID 66356 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1.N1C=CC=CC=1.[C:23](OC(=O)C)(=[O:25])[CH3:24]>O>[C:23]([NH:1][C:2]1[CH:3]=[C:4]([C:8]2[O:9][C:10]3[C:11]([N:16]=2)=[N:12][CH:13]=[CH:14][CH:15]=3)[CH:5]=[CH:6][CH:7]=1)(=[O:25])[CH3:24]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 7918Acetic AnhydrideHCID 6110863-(Oxazolo[4,5-b]pyridin-2-yl)aniline

생성물 1

HCID 2995970N-(3-(Oxazolo[4,5-b]pyridin-2-yl)phenyl)acetamide

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 0.63 g. of 2-(3-aminophenyl)oxazolo[4,5-b]pyridine in 10 ml. of pyridine was treated with 0.35 ml. of acetic anhydride with stirring. After stirring over the weekend the mixture was diluted to 50 ml. with water. After stirring a short time and cooling, the precipitate was collected, washed with water and dried. Recrystallization from ethyl acetate gave 2-(3-acetamidophenyl)oxazolo[4,5-b]pyridine, m.p. 201.5-202.5.

후처리

  1. additionwas diluted to 50 ml
  2. stirringAfter stirring a short time
  3. temperaturecooling
  4. customthe precipitate was collected
  5. washwashed with water
  6. customdried
  7. customRecrystallization from ethyl acetate

출처 및 근거

ORD 기록
ord-c8282c7f83c448a3bc9223f140a8bc7b
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131677

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