Tetrahydrofuran → tert-Butyl-4-(7-amino-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)piperidine-1-carboxylate
반응식
[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:24][cH:25]1)[N:6]([CH:11]1[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10]2.[CH2:36]1[O:37][CH2:38][CH2:39][CH2:40]1.[CH3:27][Si:28]([N-:31][Si:29]([CH3:30])([CH3:32])[CH3:33])([CH3:34])[CH3:35].[Li+:26].[O:43]=[C:44]([CH:45]=[CH:46][c:47]1[cH:48][cH:49][cH:50][cH:51][cH:52]1)[CH:53]=[CH:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1.[O:61]=[C:62]([CH:63]=[CH:64][c:65]1[cH:66][cH:67][cH:68][cH:69][cH:70]1)[CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1.[O:79]=[C:80]([CH:81]=[CH:82][c:83]1[cH:84][cH:85][cH:86][cH:87][cH:88]1)[CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1.[Pd:41].[Pd:42]>>[c:2]1([NH2:31])[cH:3][c:4]2[c:5]([cH:24][cH:25]1)[N:6]([CH:11]1[CH2:12][CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]1)[CH2:7][CH2:8][CH2:9][CH2:10]2
