Imidazole → Trimethyl[(oct-1-yn-4-yl)oxy]silane

HRID 66401

반응식

HRID 66401 반응식
[OH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5].N1C=CN=C1.Cl[Si:16]([CH3:19])([CH3:18])[CH3:17]>CN(C)C=O>[CH3:17][Si:16]([CH3:19])([CH3:18])[O:1][CH:2]([CH2:6][CH2:7][CH2:8][CH3:9])[CH2:3][C:4]#[CH:5]

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 6397ChlorotrimethylsilaneHCID 1036561-Octyn-4-ol

생성물 1

HCID 12786181Trimethyl[(oct-1-yn-4-yl)oxy]silane

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a cold solution of 166 g of 4-hydroxy-1-octyne [Prostaglandins, 10, 289 (1975)] , and 240 g of imidazole in one liter of dimethylformamide is added dropwise 202 g of chlorotrimethylsilane. The mixture is allowed to stand at room temperature for 2 to 3 days. The mixture is partitioned with water and hexane. The hexane layer is washed with brine, dried over magnesium sulfate, and concentrated. Distillation of the residue gives a colorless liquid, b.p. 38° (0.2mm).

후처리

  1. customThe mixture is partitioned with water and hexane
  2. washThe hexane layer is washed with brine
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated
  5. distillationDistillation of the residue
  6. customgives a colorless liquid, b.p. 38° (0.2mm)

출처 및 근거

ORD 기록
ord-3568b4a541224a9686c22814bb253b2e
출처 데이터셋
uspto-grants-1978_12
특허 번호
US04131737

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