Hydrochloric Acid → 3-(1-Methyl-2-pyrrolylcarbonyl)propionic acid

HRID 66536

반응식

HRID 66536 반응식
[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[CH:7]=[O:8].CN1C=CC=C1C(N1CCOCC1)C#N.[C:24]([O:28]CC)(=[O:27])[CH:25]=[CH2:26].Cl>>[CH3:1][N:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:26][CH2:25][C:24]([OH:28])=[O:27])=[O:8]

참가 물질

5

실험 절차

As for Example 6, 1-methyl-2-pyrrolecarboxaldehyde is converted to α-(1-methyl-2-pyrrolyl)-4-morpholineacetonitrile. The preceding compound is reacted with ethyl acrylate and the resulting 1,4-addition product is heated at 100° C. with 6 N hydrochloric acid to give 3-(1-methyl-2-pyrrolylcarbonyl)propionic acid.

출처 및 근거

ORD 기록
ord-8c85ff01860947939b7ac9ab9180f46c
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342691

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