Methyl iodide → 2-Imino-3,5-dimethyl-4-(1,3,4)-thiadiazoline hydroiodide

HRID 66563

반응식

HRID 66563 반응식
[CH3:1][I:2].[NH2:3][C:4]1[S:5][C:6]([CH3:9])=[N:7][N:8]=1>C(O)(C)C>[IH:2].[NH:3]=[C:4]1[N:8]([CH3:1])[N:7]=[C:6]([CH3:9])[S:5]1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 669491,3,4-Thiadiazole, 2-amino-5-methyl-

생성물 1

HCID 705411252-Imino-3,5-dimethyl-4-(1,3,4)-thiadiazoline hydroiodide

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

64.1 g of methyl iodide are added to a solution of 17.6 g of 2-amino-5-methyl-1,3,4-thiadiazole in 350 ml isopropanol. The solution is refluxed for 15 hours. The reaction mixture is then evaporated to dryness, the crystalline evaporation residue is stirred with ethyl acetate and the solvent is filtered off with suction. The crystalline residue is washed, first with ethyl acetate and then with ether, and then dried. 2-Imino-3,5-dimethyl-4-(1,3,4) -thiadiazoline hydroiodide with a melting point of 208° (decomposition) is thus obtained.

후처리

  1. temperatureThe solution is refluxed for 15 hours
  2. customThe reaction mixture is then evaporated to dryness
  3. filtrationthe solvent is filtered off with suction
  4. washThe crystalline residue is washed, first with ethyl acetate
  5. dry with materialwith ether, and then dried

출처 및 근거

ORD 기록
ord-bf3f6cd9eeb340b9976ab9527da93279
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04342764

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