Sulfuric Acid → 5-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole

HRID 66820

반응식

HRID 66820 반응식
Cl.[CH2:2]([O:9][C:10]1[CH:15]=[CH:14][C:13]([NH:16]N)=[CH:12][CH:11]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[Cl:18][C:19]1[CH:20]=[C:21]([CH2:25][C:26](=O)[CH3:27])[CH:22]=[CH:23][CH:24]=1.S(=O)(=O)(O)O>C(O)C>[CH2:2]([O:9][C:10]1[CH:15]=[C:14]2[C:13](=[CH:12][CH:11]=1)[NH:16][C:26]([CH3:27])=[C:25]2[C:21]1[CH:22]=[CH:23][CH:24]=[C:19]([Cl:18])[CH:20]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

참가 물질

5

반응물 3

HCID 1118Sulfuric AcidHCID 27340971-(3-Chlorophenyl)propan-2-oneHCID 3016725(4-(Benzyloxy)phenyl)hydrazine monohydrochloride

생성물 1

HCID 205292015-Benzyloxy-3-(3-chloro-phenyl)-2-methyl-1H-indole

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

An amount of 11.7 g (47 m mole) of 4-benzyloxyphenylhydrazine-hydrochloride and 6.39 g (38 m mole) of (3-chlorophenyl)-acetone was dissolved in 35 ml of absolute ethanol, and after addition of 2.7 ml of concentrated sulfuric acid the mixture was refluxed for five hours. After the ethanol was distilled off, the residue was mixed with water and extracted with chloroform. The extracts were dried over sodium sulfate and evaporated. The evaporation residue was purified by chromatography on silicagel by using toluene as solvent.

후처리

  1. temperaturewas refluxed for five hours
  2. distillationAfter the ethanol was distilled off
  3. additionthe residue was mixed with water
  4. extractionextracted with chloroform
  5. dry with materialThe extracts were dried over sodium sulfate
  6. customevaporated
  7. customThe evaporation residue was purified by chromatography on silicagel

출처 및 근거

ORD 기록
ord-f34ce889d3be4b0e8cb3c4cfd7a91c36
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

연결된 노트

불러오는 중…