Benzyl Bromide → 5-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester

HRID 66824

반응식

HRID 66824 반응식
[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([OH:21])=[CH:10][CH:9]=2)=[O:5])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:28](Br)[C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1>CC(CC)=O>[CH2:1]([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([C:14]=1[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[CH:12][C:11]([O:21][CH2:28][C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=1)=[CH:10][CH:9]=2)=[O:5])[CH3:2]

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 11550917Ethyl 5-hydroxy-3-phenyl-1H-indole-2-carboxylate

생성물 1

HCID 47778625-benzyloxy-3-phenyl-1H-2-indole-carboxylic acid ethylester

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

Twenty-six grams (92.4 m mole) of 5-hydroxy-3-phenyl-1H-2-indole carboxylic acid ethylester were refluxed for four days with 27.6 g of potassium carbonate and 11 ml (92.4 mole) of benzylbromide in 700 ml of methyl-ethylketone. After filtration and evaporation, the residue was chromatographed on silicagel (solvent: toluene).

후처리

  1. filtrationAfter filtration and evaporation
  2. customthe residue was chromatographed on silicagel (solvent: toluene)

출처 및 근거

ORD 기록
ord-0cfe56dcc81144c48b41a140a5ebcfd0
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

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