Water → 2-[2-(4-Acetamido-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

HRID 66899노트

반응식

HRID 66899 반응식
[CH2:1]([O:3][C:4](=[O:29])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH3:20])[C:13]([C:21]1[CH:26]=[CH:25][C:24]([NH2:27])=[CH:23][CH:22]=1)=[C:12]2[CH3:28])([CH3:7])[CH3:6])[CH3:2].C(N(CC)CC)C.[C:37](Cl)(=[O:39])[CH3:38].O>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:29])[C:5]([O:8][C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[N:14]([CH2:18][CH2:19][CH3:20])[C:13]([C:21]1[CH:22]=[CH:23][C:24]([NH:27][C:37](=[O:39])[CH3:38])=[CH:25][CH:26]=1)=[C:12]2[CH3:28])([CH3:6])[CH3:7])[CH3:2]

참가 물질

6

반응물 4

HCID 962WaterHCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 538662912-[2-(4-amino-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

생성물 1

HCID 537871562-[2-(4-Acetamido-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

One gram (2.53 m mole) of 2-[2-(4-amino-phenyl)-3-methyl-1-propyl-1H-indole-5-yloxy]-2-methyl-propanoic acid ethylester and 0.25 g (2.5 m mole) of triethylamine were dissolved in 15 ml of chloroform and 0.2 g (2.55 m mole) of acetyl chloride were added dropwise while ice-cooling. After a few hours at room temperature the reaction mixture was mixed with water and extracted with chloroform. The chloroform extracts were dried and evaporated, and the residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1)).

후처리

  1. temperaturecooling
  2. extractionextracted with chloroform
  3. dry with materialThe chloroform extracts were dried
  4. customevaporated
  5. customthe residue was purified by chromatography on silicagel (solvent: toluene/acetone (5:1))

출처 및 근거

ORD 기록
ord-edf9e13b99db4fcbb578d2343b4e2b70
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343811

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