Toluene → 5-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole

HRID 66935

반응식

HRID 66935 반응식
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=1.[C:11]1([CH3:20])[C:12]([C:17](Cl)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1.C1(C)C=CC=CC=1>C1(C)C(C)=CC=CC=1>[C:11]1([CH3:20])[C:12]([C:17]([NH:1][C:2]2[S:6][N:5]=[C:4]([C:7]([Cl:10])([Cl:9])[Cl:8])[N:3]=2)=[O:18])=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 1140TolueneHCID 702762-Methylbenzoyl chlorideHCID 6028483-(Trichloromethyl)-1,2,4-thiadiazol-5-amine

생성물 1

HCID 130415145-(2-Toluamido)-3-Trichloromethyl-1,2,4-Thiadiazole수율 35.1%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

A solution of 22.0 g (0.1 mole) 5-amino-3-trichloromethyl-1,2,4-thiadiazole and 16.0 g (0.1 mole) 2-toluoyl chloride in 250 ml xylene was heated at reflux for 20 hours. The reaction mixture was cooled to room temperature and the resulting precipitate removed by filtration. Following recrystallization for toluene, 11.8 g (35% yield) of pure product was otained; m.p. 170° C.

후처리

  1. temperatureat reflux for 20 hours
  2. customthe resulting precipitate removed by filtration

출처 및 근거

ORD 기록
ord-40e39dbc987749c18435765ac008b42e
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04343945

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