3-Chlorophthalic anhydride → 3-Fluorophthalic anhydride

반응식

Cl[C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6].[F-:13].[K+]>>[F:13][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6]

참가 물질

반응물 2

HCID 670143-Chlorophthalic anhydride

HCID 522689Potassium Fluoride

생성물 1

HCID 695513-Fluorophthalic anhydride수율 69%

반응 조건

온도: 235 °C

실험 절차

A mixture of 20 parts of 3-chlorophthalic anhydride, and 20 parts of anhydrous potassium fluoride was heated and maintained at about 235° C. for about 9 hours. The reaction mixture was then cooled and the crude product removed by vaccum distillation and recrystallized from chloroform to yield 12.65 parts of purified 3-fluorophthalic anhydride (69% yield).

후처리

temperaturewas heated
temperatureThe reaction mixture was then cooled
customthe crude product removed by vaccum distillation
customrecrystallized from chloroform

출처 및 근거

ORD 기록: ord-42b2a6f74dd5429695d292be7a7d85bf
출처 데이터셋: uspto-grants-1982_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04343951

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