Sodium borohydride → 1-Bromo-trans-1-octen-3-ol
반응식
[BH4-].[Na+].[Br:3]/[CH:4]=[CH:5]/[C:6](=[O:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11].Cl/C=C/C(=O)CCCCC>C(O)C>[Br:3]/[CH:4]=[CH:5]/[CH:6]([OH:12])[CH2:7][CH2:8][CH2:9][CH2:10][CH3:11]참가 물질
5
실험 절차
To an ice cooled mixture of 14.29 g. (0.378 mole) of sodium borohydride in 400 ml. of anhydrous ethanol is added the crude 1-bromo-trans-1-octen-3-one (Example 725), from 0.424 mole of 1-chloro-trans-1-octen-3-one) over 30 minutes. The mixture is stirred for 2 hours with ice cooling and is then partitioned between ice water and benzene. The organic phase is washed with water and saturated brine, dried (Na2SO4), and evaporated to an oil. Fractional distillation yields the title compound as a colorless oil, b.p. 66°-68° C. (0.025 torr).
후처리
- additionmixture of 14.29 g
- customis then partitioned between ice water and benzene
- washThe organic phase is washed with water and saturated brine
- dry with materialdried (Na2SO4)
- customevaporated to an oil
- distillationFractional distillation
출처 및 근거
- ORD 기록
- ord-7ccd459c441e4a12a41d3f3fa207264e
- 출처 데이터셋
- uspto-grants-1982_08
- 특허 번호
- US04343949
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