Bromide ion → 1-Bromo-5,5-dimethyl-3-tetrahydropyranyloxy-trans-1-octene
반응식
[CH3:1][C:2]([CH3:17])([CH2:14][CH2:15][CH3:16])[CH2:3][CH:4]([O:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9]1)[C:5]#[CH:6].C(BC(C(C)C)C)(C(C)C)C.[Br-:29]>C(Cl)(Cl)(Cl)Cl>[Br:29]/[CH:6]=[CH:5]/[CH:4]([O:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][O:9]1)[CH2:3][C:2]([CH3:17])([CH3:1])[CH2:14][CH2:15][CH3:16]참가 물질
5
실험 절차
Treatment of 7.15 g. (30 moles) of 5,5-dimethyl-3-tetrahydropyranyloxy-1-octyne (Example 999) with 33 moles of disiamylborane in carbon tetrachloride followed by 30 moles of bromide in carbon tetrachloride, refluxing the resulting mixture, and isolation by chromatography on silica gel, all as described in Example 1173 gives the title compound.
후처리
- temperaturerefluxing the resulting mixture, and isolation by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-55e64883fee24b6ea05fa4b8ed6c1f3a
- 출처 데이터셋
- uspto-grants-1982_08
- 특허 번호
- US04343949
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