Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 67043

반응식

HRID 67043 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

참가 물질

4

반응물 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

생성물 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5 A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate 160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as is in the subsequent ketene reaction.

후처리

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customas is in the subsequent ketene reaction

출처 및 근거

ORD 기록
ord-3018eb2cab444799be1cee45777264b6
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344885

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