Hydrochloric Acid → 2-Benzyl-(alpha-vinyl)-benzyl alcohol

HRID 67123

반응식

HRID 67123 반응식
[CH:1]([Mg]Cl)=[CH2:2].[CH2:5]([C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH:14]=[O:15])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[Cl-].[NH4+].Cl>O1CCCC1>[CH2:5]([C:12]1[CH:19]=[CH:18][CH:17]=[CH:16][C:13]=1[CH:14]([OH:15])[CH:1]=[CH2:2])[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 100129102-BenzylbenzaldehydeHCID 178461836HCID 178461836, 화합물

생성물 1

HCID 537702942-Benzyl-(alpha-vinyl)-benzyl alcohol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

30 ml of a 1.6 molar solution of vinyl-magnesium chloride in tetrahydrofuran are introduced into 100 ml of absolute tetrahydrofuran at 0° C. 9.8 g (0.05 mole) of 2-benzylbenzaldehyde in 100 ml of absolute tetrahydrofuran are added dropwise whilst stirring and excluding moisture. The reaction mixture is stirred for 3 hours at 25° C. and is then cautiously decomposed by adding a cold saturated ammonium chloride solution and a few milliliters of 10% strength hydrochloric acid until the precipitate dissolves. The mixture is then extracted by shaking three times with ether and the combined ether phases are washed with sodium bisulfite solution, sodium bicarbonate solution and water, dried over sodium sulfate and concentrated under reduced pressure. 9.4 g of a yellowish oil, which is sufficiently pure for the further reactions, are obtained; nD21 =1.5855.

후처리

  1. stirringThe reaction mixture is stirred for 3 hours at 25° C.
  2. dissolutiondissolves
  3. extractionThe mixture is then extracted
  4. stirringby shaking three times with ether
  5. washthe combined ether phases are washed with sodium bisulfite solution, sodium bicarbonate solution and water
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated under reduced pressure
  8. customare obtained

출처 및 근거

ORD 기록
ord-6e0aa55930224ed08f546ba417ad8acc
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04344961

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