Nitrofungin → 4-Amino-2-chlorophenol

HRID 67157

반응식

HRID 67157 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[OH:11].[H][H]>O1CCCC1.[Ni]>[NH2:8][C:6]1[CH:5]=[CH:4][C:3]([OH:11])=[C:2]([Cl:1])[CH:7]=1

참가 물질

5

반응물 2

HCID 12074NitrofunginHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 775784-Amino-2-chlorophenol

시약·촉매·용매 2

HCID 935Nickel촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 86.8 g of 2-chloro-4-nitrophenol in 200 ml of tetrahydrofuran containing 2 g of Raney nickel catalyst was hydrogenated in a Parr shaker at 50 p.s.i. hydrogen pressure. The mixture was filtered and the solvent was evaporated from the filtrate. The residue was recrystallized from ether to give 4-amino-2-chlorophenol (1A), as a tan solid, mp: 144°-147° C.

후처리

  1. filtrationThe mixture was filtered
  2. customthe solvent was evaporated from the filtrate
  3. customThe residue was recrystallized from ether

출처 및 근거

ORD 기록
ord-67c7ef7a201648e7a36113cb54725f0d
출처 데이터셋
uspto-grants-1982_08
특허 번호
US04345076

연결된 노트

불러오는 중…