Triphenylphosphine → (3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide

HRID 6716

반응식

HRID 6716 반응식
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][CH2:22][CH2:23][N:24]1[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]2[C:25]1=[O:34]>C1(C)C=CC=CC=1>[Br-:20].[C:25]1(=[O:34])[N:24]([CH2:23][CH2:22][CH2:21][P+:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:28](=[O:29])[C:27]2=[CH:30][CH:31]=[CH:32][CH:33]=[C:26]12

참가 물질

4

반응물 2

HCID 11776TriphenylphosphineHCID 21611N-3-Bromopropylphthalimide

생성물 1

HCID 22018487(3-(1,3-Dioxoisoindolin-2-yl)propyl)triphenylphosphonium bromide수율 46.1%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

The 3-phthalimidopropyltriphenylphosphonium bromide was prepared as follows. To a solution of triphenylphosphine (24.5 g, Aldrich, U.S.A.) in toluene (200 mL) was added N-(3-bromopropyl)phthalimide (25 g, Aldrich, U.S.A.). The mixture was heated to reflux overnight. The white solid so formed was isolated by filtration and dried under vacuum to yield 3-phthalimidopropyltriphenylphosphonium bromide (22.8 g).

후처리

  1. customThe 3-phthalimidopropyltriphenylphosphonium bromide was prepared
  2. temperatureThe mixture was heated
  3. temperatureto reflux overnight
  4. customThe white solid so formed
  5. customwas isolated by filtration
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-e96b0f6e3a4f4f18982b5bc493f3a1d2
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07084154B2

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